GIFT-ZIFT

GIFT and ZIFT can be used to treat many types of infertility, except in cases where there is damage to or abnormalities of the fallopian tubes. These techniques can also be used in cases of mild male infertility, as long as the sperm is capable of fertilizing an egg. If the woman is not capable of producing eggs that can be used in GIFT, but her partner’s sperm is capable of fertilization, they might consider getting eggs from a donor. One reason for using an egg donor is age. Women over age 35 are less likely to have viable eggs and more likely to have children with birth defects than younger women. A woman with premature ovarian failure, a condition in which menopause has begun early, might also consider a donor if she wants to carry a child. Most egg donation is anonymous, but some couples prefer to know their egg donor and take legal steps to contract for the donation of the eggs.

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ART is sometimes used as a catchall term for any fertility treatment, from medications to surgery. But in the medical community, ART refers to treatments that manipulate the sperm or the egg to make pregnancy more likely.

ART works best in couples who have an issue with sperm or who have a diagnosis that makes it difficult for the sperm to fertilize the egg. Women who ovulate infrequently may also benefit from ART, since an ART cycle greatly increases the odds of a successful pregnancy each cycle.

ART is also a viable option in couples who have unexplained infertility. This is because the odds of pregnancy are higher with each ART cycle, and ART can circumvent many common but difficult-to-diagnose problems. Couples who have tried other treatments without success, as well as people attempting to get pregnant without a partner, may also choose ART.

Success of pregnancy with IVF is very dependent upon the age of the woman and her eggs.  Studies show that success of IVF is significantly reduced after the age of 43.

The average cost for one in vitro fertilization (IVF) cycle is $12,000. Basic IVF can be as much as $15,000 or may be as low as $10,000. It’s rarely lower than that. These numbers do not include the cost of medications, which may be as low as $1,500 or as high as $3,000 per cycle.

PGD is a procedure for testing the genetic makeup of a very early embryo created through in vitro fertilization (IVF), before it is implanted into the womb of the woman who will carry it to term. At this stage, the embryo has about eight cells, which are typically identical; they have started to multiply but have not yet begun to differentiate. One cell is extracted and analyzed; the remaining cells are capable of developing into a complete fetus.

Most IVF protocols involve hormonal treatments that hyper-stimulate women’s ovaries to produce multiple eggs, which typically generate several embryos. PGD offers a tool for selecting which embryo(s) to implant in a woman’s uterus.

Intracytoplasmic Sperm Injection (ICSI) is considered absolutely necessary is in the case of male factor infertility with an abnormal semen analysis. In the Bay Area, however, about 75 percent of all IVF cases are now ICSI. Patients are electing to undergo ICSI for reasons other than male factor infertility, including:

• Previous poor fertilization with IVF
• Variable sperm counts
• Unexplained infertility

Many patients choose to undergo the ICSI procedure in order to maximize their success even when the procedure is not clearly indicated.

If you have been told that there are abnormalities with any sperm test results, you should give serious consideration to ICSI. If the male partner has had a vasectomy reversal, we also recommend ICSI regardless of the sperm quality because of the presence of sperm antibodies that may affect fertilization.

The decision to proceed with ICSI is particularly difficult if there is no prior evidence of male factor infertility. Some couples choose ICSI because they want to do everything possible to maximize fertilization. However, it is important to understand that for many couples with normal sperm parameters, maximal fertilization can be achieved with standard insemination during IVF without the use of ICSI.

Gamete intrafallopian transfer. Gamete intrafallopian transfer (GIFT) is a tool of assisted reproductive technology against infertility. Eggs are removed from a woman’s ovaries, and placed in one of the Fallopian tubes, along with the man’s sperm.

ZIFT is an assisted reproductive procedure similar to in vitro fertilization and embryo transfer, the difference being that the fertilized embryo is transferred into the fallopian tube instead of the uterus.

Because the fertilized egg is transferred directly into the tubes, the procedure is also referred to as tubal embryo transfer (TET).

This procedure can be more successful than gamete intrafallopian transfer (GIFT) because your physician has a greater chance of ensuring that the egg is fertilized. The woman must have healthy tubes for ZIFT to work.

The main difference between ZIFT and GIFT is that ZIFT transfers a fertilized egg directly into the fallopian tubes while GIFT utilizes a mixture of sperm and eggs.